Ipamorelin is a synthetic pentapeptide growth-hormone secretagogue with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2. Published pharmacology identified it as a selective agonist at the growth-hormone-secretagogue receptor.

Research context

The foundational selectivity study used rat pituitary cells, anaesthetized rats, and conscious swine. In that work, ipamorelin released growth hormone without statistically significant ACTH or cortisol elevation relative to GHRH; this must not be converted into an absolute, species-independent claim.

Common analytical research areas

• GHSR binding and growth-hormone-secretagogue structure-activity relationships.
• Comparative secretagogue selectivity in validated cell and animal models.
• Intracellular signaling downstream of GHSR activation.

Selected scientific references

• Ipamorelin selectivity and pharmacology (PMID 9849822)

Research-use notice: Supplied exclusively for laboratory research and analytical use. Not for human or veterinary use, diagnosis, treatment, food, cosmetic, or household use.

Specification record updated 26 Sept 2026. External database links are provided for research context; verify primary sources before analytical use.